Osteoarthritis (OA) is one of the most common causes of joint discomfort and disability. Since its prevalence increases with age, the global rise in the geriatric population portends an increased burden of this disease on individuals and the health care system. Hirudotherapy may offer another therapeutic option to reduce the pain and debility caused by OA. However, additional studies with robust methodology and adequate sample size are needed to better evaluate whether hirudotherapy should be among standard clinical practice for OA treatment.